Neurodevelopmental disorders Dr Susana Ribeiro dos Louros Chancellor’s Fellow Hugh Robson Building 15 George Square Edinburgh EH8 9XD Contact details Email: slouros@ed.ac.uk Personal profile 2023 - present: Chancellor's Fellow, Centre for Discovery Sciences, University of Edinburgh. 2015 - 2023: Postdoctoral Fellow, Centre for Discovery Brain Sciences, University of Edinburgh 2012 - 2015: Postdoctoral Fellow, Centre for Neuroscience and Cell Biology, University of Coimbra, Portugal 2007 - 2012: Ph.D. in Biology (Magna cum laude), University of Coimbra, Portugal Research Theme Synapses, Circuits and Behaviour Research Our research will focus on understanding how the ubiquitin proteasome system function contributes to brain development and its dysfunction leads to neurodevelopmental disorders. Funding SIDB - Simons Initiative for the Developing Brain Collaborations Dr. Ana Luísa Carvalho, Glutamatergic Synapses Biology, Center for Neuroscience and Cell Biology, University of Coimbra, Portugal Dr. Chinfei Chen, Synaptic plasticity and circuit remodeling during development, F.M. Kirby Neurobiology Center, Harvard, Medical School, Boston, USA Dr. Ka wan Li, Neuroproteomics: State-of-the-art quantitative proteomics techniques, Department of Neurosciences-CNCR, Vrije Universiteit Amsterdam, Holland Dr. Ugo Mayor, Neuronal Ubiquitin Pathway, Department of of Biochemistry at the University of the Basque Country, Spain Dr. Peter Kind, Simons Initiative for the Developing Brain, University of Edinburgh, Hugh Robson Building, George Square, Edinburgh, UK Publications (2023) Louros SR*, Seo S*, Maio B, Martinez-Gonzalez C, Gonzalez-Lozano MA, Muscas M Verity NC, Wills JC, Li KW, Nolan MF and Osterweil EK. Excessive proteostasis contributes to the pathology in Fragile X Syndrome. Neuron (in press) *co-first author (2022) Seo S*, Louros SR*, Anstey N, Gonzalez-Lozano MA, Harper CB, Verity NC, Dando O, Thomson SR, Darnell JC, Kind PC, Li KW, and Osterweil EK. Excess ribosomal protein production unbalances translation in Fragile X Syndrome. Nature Communications 13, 3236. *co-first author (2022) Caldeira G*, Inácio A*, Beltrão N, Barreto C, Rodrigues M, Rondão T, Macedo R, Gouveia R, Edfawy M, Guedes J, Cruz B, Louros SR, Moreira I, Peça J and Carvalho AL. Aberrant hippocampal transmission and behaviour in mice with a stargazin mutation linked to intellectual disability. Molecular Psychiatry. Mar 7. doi: 10.1038/s41380-022-01487 (2020) Muscas M*, Seo SS*, Louros SR*, Osterweil EK. A Differential Effect of Lovastatin versus Simvastatin in Neurodevelopmental Disorders. eNeuro. 2020 Aug 13;7(4):ENEURO.0162-20.2020. *co-first author (2019) Muscas M, Louros SR, Osterweil EK. Lovastatin, not simvastatin, corrects core phenotypes in the fragile X mouse model. eNeuro. 2019 Jun 12;6(3):ENEURO.0097-19.2019. doi: 10.1523/ENEURO.0097-19.2019 (2019) Asiminas A*, Jackson AD*, Louros SR#, Till SM#, Spano T, Dando O, Bear MF, Chattarji S, Hardingham GE, Osterweil EK, Wyllie DJA, Wood ER, Kind PC. Sustained correction of associative learning deficits following brief, early treatment in a rat model of Fragile X Syndrome. Science Translational Medicine. 2019 May 29;11(494):eaao0498. # co-second author (2018) Louros SR, Caldeira GL, Carvalho AL. Stargazin Dephosphorylation Mediates Homeostatic Synaptic Downscaling of Excitatory Synapses. Front Mol Neurosci. Sep 13;11:328. doi: 10.3389/fnmol.2018.00328. eCollection 2018. (2017) Thomson SR*, Seo SS*, Barnes SA#, Louros SR#, Muscas M, Dando O, Hardingham GE, Wyllie DJA, Kind PC, Osterweil EK. Cell type-specific translation profiling reveals a novel strategy for treating fragile X syndrome. Neuron. Aug 2;95(3):550-563. # co-second author (2016) Louros, S. R., Osterweil, E. K. Perturbed proteostasis in autism spectrum disorders. Journal of Neurochemistry. Dec;139(6):1081-1092. doi: 10.1111/jnc.13723. Epub 2016 Aug 4. (2014) Louros SR, Hooks BM, Litvina L, Carvalho AL and Chen C. A role for stargazin in experience-dependent plasticity. Cell Reports. 2014; 7(5): 1614-1625. Information for students: Willingness to discuss research projects with undergraduate and postgraduate students: YES - please click here This article was published on 2023-04-04
