Synapses, circuits and behaviour

Neurons are the fundamental building blocks of the nervous system and unravelling the mechanisms that regulate neuronal excitability, communication and plasticity is key to understanding how the nervous system controls complex behaviours.

In this research theme, investigators exploit advanced imaging, electrophysiological, molecular genetic and quantitative behavioural approaches to understand the cellular and circuit mechanisms underpinning nervous system functions such as sensory perception, memory formation and the control of complex, adaptable behaviours in the healthy and diseased brain.

Our aim is to translate fundamental discoveries, through development of animal- and human-based models, to generate transformative therapeutic interventions for disorders that affect nervous system function.

Theme Lead: Prof Ian Duguid