Highly differentiated tissues, such as the central nervous system, are constantly exposed to a variety of challenges.
These include mechanical injury, degeneration, inflammation, and uncontrolled growth. In this theme, groups cooperate to discover the cellular and molecular mechanisms that underpin cell and tissue differentiation, resilience to injury, and repair processes.
We employ a variety of cellular models, model organisms, and screening approaches. This maximises synergy between groups in making fundamental discoveries and expediting translation of these to clinical research.
Theme Lead:
| Name | Research interest |
|---|---|
| Fowler, Jill | Mechanisms of neurodegeneration in stroke and dementia |
| Hall, Andrew | Chondrocytes, cartilage and osteoarthritis |
| Paxton, Jennifer | Musculoskeletal tissue engineering |
| Sieger, Dirk | Microglia-tumour interactions |
| Torsney, Carole | Somatosensory plasticity |
| Wyllie, David | Physiology and pharmacology of ion channels |