Robin Beaven discovers a novel developmental mechanism that patterns the proximo-distal axis of the fly renal tubule:
Early patterning followed by tissue growth establishes distal identity in Drosophila Malpighian tubules
Published in Frontiers in Cell and Developmental Biology
https://doi.org/10.3389/fcell.2022.947376
Luigi Zechini et al show the mechanically-activated ion channel, Piezo, is an important component of the fly heart’s ability to adapt to mechanical force:
Piezo buffers mechanical stress via modulation of intracellular Ca2+ handling in the Drosophila heart
Published in Frontiers in Physiology
https://doi.org/10.3389/fphys.2022.1003999
Sybille Koehler finds the mechanosensor, Cheerio, provides a key protective role in fly nephrocytes (insect filtration cells that resemble kidney podocytes) depleted of their filtration apparatus.
A protective role for Drosophila Filamin in nephrocytes via Yorkie mediated hypertrophy
Published in Life Science Alliance