Three new papers from the Denholm lab

Well done to Robin Beaven, Luigi Zechini and Sybille Koehler (Denholm lab) on their latest publications.

Robin Beaven discovers a novel developmental mechanism that patterns the proximo-distal axis of the fly renal tubule:

Early patterning followed by tissue growth establishes distal identity in Drosophila Malpighian tubules

Published in Frontiers in Cell and Developmental Biology


Luigi Zechini et al show the mechanically-activated ion channel, Piezo, is an important component of the fly heart’s ability to adapt to mechanical force:

Piezo buffers mechanical stress via modulation of intracellular Ca2+ handling in the Drosophila heart

Published in Frontiers in Physiology


Sybille Koehler finds the mechanosensor, Cheerio, provides a key protective role in fly nephrocytes (insect filtration cells that resemble kidney podocytes) depleted of their filtration apparatus.     

A protective role for Drosophila Filamin in nephrocytes via Yorkie mediated hypertrophy

Published in Life Science Alliance

DOI: 10.26508/lsa.202101281