My work is primarily the creation, development, and curation of a comprehensive model of dendritic spine biochemical signalling dynamics. This takes the form of a model of a glutamatergic CA1 spine, and is based on AMPA receptor functionality. Contact type Person First name Richard Surname Fitzpatrick Title Mr Role PhD Student - Stefan Lab Organisation 1 Hugh Robson Building Organisation 2 15 George Square Organisation 3 Edinburgh, EH8 9XD Work phone +44 (0) 131 651 1131 Email s0903715@sms.ed.ac.uk Personal Profile BSc Biological Sciences (Neuroscience), University of Edinburgh Research Assistant (Morris lab), University of Edinburgh MSc Cognitive Science, University of Edinburgh Research My work is primarily the creation, development, and curation of a comprehensive model of dendritic spine biochemical signalling dynamics. This takes the form of a model of a glutamatergic CA1 spine, and is based on AMPA receptor functionality. The aim of the model is two-fold. First, it is to provide a tool for researchers to investigate interactions between complex signalling pathways, and to compare this to isolated in vitro work, as well as in vivo data. Second, to use the model to elucidate how these pathways effect AMPA receptor properties, from phosphorylation rates to ubiquitination, recycling, and synthesis. I am also building a rule-based model of AMPA receptors at the synapse to explore conductance profiles and receptor stability in relation to plasticity-inducing events. This article was published on 2022-10-17
Contact type Person First name Richard Surname Fitzpatrick Title Mr Role PhD Student - Stefan Lab Organisation 1 Hugh Robson Building Organisation 2 15 George Square Organisation 3 Edinburgh, EH8 9XD Work phone +44 (0) 131 651 1131 Email s0903715@sms.ed.ac.uk
