Dr Julia Schiemann

The ability to perform precise, coordinated movements is crucial for almost all aspects of our daily life. But how is the generation of cortical motor commands shaped by neuromodulators to facilitate flexible motor behaviours?

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Personal profile

  • 2015 – present    Research Fellowship German Research Foundation (i.e. Deutsche Forschungsgemeinschaft, DFG); University of Edinburgh, UK
  • 2013 – 2015    Leopoldina-Postdoc-Fellowship German National Academy of Sciences (i.e. Nationale Akademie der Wissenschaften); University of Edinburgh, UK
  • 2006 – 2012    PhD in Neuroscience; Goethe-University Frankfurt, Germany
  • 2007 – 2009    Doctoral Scholarship German National Academic Foundation (i.e. Studienstiftung des deutschen Volkes)
  • 2000 – 2005    Diploma in Human Biology, University of Marburg, Germany

Research

Cortical information processing is under potent neuromodulatory control. I am investigating how neuromodulators such as noradrenaline shape neuronal activity in the motor cortex and control complex movements.

To address this I employ a multi-level strategy combining in vivo patch-clamp electrophysiology, quantitative behavioural paradigms, virus-based circuit mapping, selective pharmacology and in vivo optogenetics.

Funding

  • Deutsche Forschungsgemeinschaft (DFG)

Collaborations

  • Dr Tony Pickering, School of Physiology, Pharmacology & Neuroscience, University of Bristol
  • Dr Gaby Schneider, Institute of Mathematics, Goethe-University Frankfurt

Recent publications

J. Schiemann*, P. Puggioni*, J. Dacre, M. Pelko, A. Domanski, M. v. Rossum, I. Duguid (*shared first authors) Cellular mechanisms underlying behavioral state-dependent bidirectional modulation of motor cortex output; Cell Reports, 2015, 11(8):1319-30

J. Schiemann, F. Schlaudraff, V. Klose, M. Bingmer, S. Seino, P. J. Magill, K. A. Zaghloul, G., Schneider, B. Liss, J. Roeper; K-ATP channels in dopamine substantia nigra neurons control bursting and novelty-induced exploration; Nature Neuroscience, 2012, 15(9): 1272-80

M. Bingmer*, J. Schiemann*, J. Roeper, G. Schneider (*shared first authors); Measuring burstiness and regularity in oscillatory spike trains; Journal of Neuroscience Methods, 2011, 201(2): 426-437

S. Krabbe, J. Duda, J. Schiemann, C. Poetschke, G. Schneider, E.R. Kandel, B. Liss, J. Roeper, E.H. Simpson; Increased dopamine D2 receptor activity in the striatum alters the firing pattern of dopamine neurons in the ventral tegmental area; PNAS, 2015, 112(12): E1498-506

E. Dragicevic, J. Schiemann, B. Liss; Dopamine midbrain neurons in health and Parkinson’s disease: Emerging roles of voltage-gated calcium channels and ATP-sensitive potassium channels; Neuroscience, 2015, 284:798-814; review article

M. Messer, M. Kirchner, J. Schiemann, J. Roeper, R. Neininger, G. Schneider; A multiple filter test for the detection of rate changes in renewal processes with varying variance; The Annals of Applied Statistics, 2014, Vol. 8, No. 4, 2027-2067

 E. Dragicevic, C. Poetschke, J. Duda, F. Schlaudraff, S. Lammel, J. Schiemann, M. Fauler, A. Hetzel, M. Watanabe, R. Lujan, R.C. Malenka, J. Striessnig, B. Liss; Cav1.3 channels control D2-autoreceptor responses via NCS-1 in substantia nigra dopamine neurons; Brain, 2014, 137(Pt8): 2287-302

 

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