I’m researching how synaptic functioning is altered in neurodegenerative disease, with the aim to elucidate pathogenic mechanisms for which therapeutics may be developed. [scald=53792:sdl_editor_representation {"alt":"","caption":""}] Personal profile 2015 – present: Postdoctoral Fellow, University of Edinburgh, UK 2015: PhD Neuroscience, McGill University, Canada 2007: BSc (Hons) Biological psychology, University of British Columbia, Canada Research Common in many neurodegenerative disorders, synaptic dysfunction is an early pathology of Huntington’s disease. To better characterize these synaptic changes, I’m performing experiments in cultured neurons from transgenic mice with the disease-causing mutation. I’m using a combination of genetically-encoded and exogenous fluorescent reporters to monitor synaptic vesicle recycling pathways in hippocampal, striatal, and cerebellar granule neurons. Funding Cure for Huntington’s Disease Initiative (CHDI) Recent publications McAdam RL, Varga K, Jiang Z, Young F, Blandford V, McPherson P, Gong L-W, & Sossin W (2015). The juxtamembrane region of synaptotagmin 1 interacts with dynamin and regulates vesicle fission. Journal of Cell Science, 132 (12) Reines A, Bernier LP, McAdam RL, Belkaid W, Shan W, Koch AW, Seguela P, Colman DR, & Dhaunchak AS (2012). N-cadherin prodomain processing regulates synaptogenesis. Journal of Neuroscience, 32 (18) Lebeau G, Miller LC, Tartas M, McAdam RL, Badeaux F, Desgroseillers L, Sossin WS, & Lacaille J-C (2011). Staufen 2 regulates mGluR long-term depression and Mab1b mRNA distribution in hippocampal neurons. Learning & Memory, 18 (5) This article was published on 2022-10-17
