Mechanisms of synapse degeneration in Alzheimer’s disease. Dr James Catterson Research Fellow 1 George Square Edinburgh, EH8 9JZ Contact details Work: +44 (0) 0131 650 4356 Email: jcatter2@exseed.ed.ac.uk Web: Spires-Jones Research Group Personal profile Image 2019 - present: Research Fellow, University of Edinburgh. 2013 - 2019: Research Fellow, University College London. 2009 - 2013: Ph.D. Cardiovascular Biology, University of Edinburgh. 2008 - 2009: MSc, Cardiovascular Biology, University of Edinburgh. 2004 - 2008: BSc, Neuroscience, University of Edinburgh. Research My research focuses on the mechanisms of synapse degeneration in Alzheimer’s disease. I use the power and speed of Drosophila genetics coupled with Array Tomography (AT), a sophisticated imaging technique, to examine why Alzheimer's proteins, such as Tau and Aβ, are so toxic to neurons. Publications Image Catterson JH, Minkley L, Aspe S, Judd-Mole S, Moura S, Dyson MC, Rajasingam A, Woodling NS, Atilano ML, Ahmad M, Durrant CS, Spires-Jones TL, Partridge L, Aβ toxicity rescued by protein retention in the ER. bioRxiv 2021.08.18.456775. Colom-Cadena M, Tulloch J, Jackson RJ, Catterson JH, Rose J, Davies C, Hooley M, Anton-Fernandez A, Dunnett S, Tempelaar R, Tzioras M, Izzo NJ, Catalano SM, Smith C, Spires-Jones TL. , TMEM97 increases in synapses and is a potential synaptic Aβ binding partner in human Alzheimer’s disease. bioRxiv 2021.02.01.428238. Catterson JH, Khericha M, Dyson MC, Vincent AJ, Callard R, Haveron SM, Rajasingam A, Ahmad M, Partridge L. Short-term, Intermittent Fasting induces long-lasting Gut Health and TOR-independent Lifespan Extension. Current Biology. 2018 Jun 4;28(11):1714-1724. Ivy JR, Drechsler M, Catterson JH, Bodmer R, Ocorr K, Paululat A, Hartley PS. Klf15 Is Critical for the Development and Differentiation of Drosophila Nephrocytes. PLoS One. 2015 Aug 24;10(8):e0134620. Catterson JH, Heck MM, Hartley PS. Fermitins, the orthologs of mammalian Kindlins, regulate the development of a functional cardiac syncytium in Drosophila melanogaster. PLoS One. 2013 May 15;8(5):e62958. Tracey CJ, Pan X, Catterson JH, Harmar AJ, Ahmood Hussain M, Hartley PS. Diurnal expression of Thrombopoietin is regulated by Clock. Journal of Thrombosis and Haemostasis. 2012 Apr;10(4):662-9. Dear JW, Simpson KJ, Nicolai MP, Catterson JH, Street J, Huizinga T, Craig DG, Dhaliwal K, Webb S, Bateman DN, Webb DJ. Cyclophilin A is a damage-associated molecular pattern molecule that mediates acetaminophen induced liver injury. Journal of Immunology. 2011 Sep 15;187(6):3347-52. Catterson JH, Knowles-Barley S, James K, Heck MMS, Harmar AJ, Hartley PS. Dietary modulation of Drosophila sleep-wake behaviour. PLoS One. 2010 Aug 10;5(8):e12062. Dear JW, Nicolai MPJ, Catterson JH, Huizinga T, Dhaliwal K, Bateman DN, Waring WS, Webb DJ, Simpson K. Cyclophilin A is a Key mediator of Paracetamol Poisoning. Clinical Toxicology. 2010 Mar 1;48(3):266-267. This article was published on 2022-10-17