My work is focused on how astrocytes and microglia in human brains ingest synapses. Dr Makis Tzioras Postdoctoral Research Fellow - Spires-Jones Lab 1 George Square Edinburgh EH8 9XD Contact details Work: 0131 650 4356 Email: mtzioras@ed.ac.uk Web: Spires-Jones Research Group Image Personal Profile Undergraduate degree at University of Edinburgh (BSc Biomedical Sciences, Hons Neuroscience) PhD at University of Edinburgh: “Glial contribution to synaptic ingestion in Alzheimer’s disease and schizophrenia”. Research My work is focused on how astrocytes and microglia in human brains ingest synapses. I am exploring this in ageing brains, Alzheimer’s disease and schizophrenia using human post-mortem tissue and novel culturing systems with human biopsies Relevant Publications Tzioras, M., Davies, C., Newman, A., Jackson, R. and Spires‐Jones, T., 2018. Invited Review: APOE at the interface of inflammation, neurodegeneration and pathological protein spread in Alzheimer's disease. Neuropathology and Applied Neurobiology, 45(4), pp.327-346. 10.1111/nan.12529 Henstridge, C., Tzioras, M. and Paolicelli, R., 2019. Glial Contribution to Excitatory and Inhibitory Synapse Loss in Neurodegeneration. Frontiers in Cellular Neuroscience, 13. 10.3389/fncel.2019.00063 Tzioras, M., Stevenson, A., Boche, D. and Spires‐Jones, T., 2020. Microglial contribution to synaptic uptake in the prefrontal cortex in schizophrenia. Neuropathology and Applied Neurobiology, 47(2), pp.346-351. 10.1111/nan.12660 Tzioras, M., Daniels, M., King, D., Popovic, K., Holloway, R., Stevenson, A., Tulloch, J., Kandasamy, J., Sokol, D., Latta, C., Rose, J., Smith, C., Miron, V., Henstridge, C., McColl, B. and Spires-Jones, T., 2019. Altered synaptic ingestion by human microglia in Alzheimer’s disease. BioRXiv https://doi.org/10.1101/795930 This article was published on 2022-10-17
