Sybille Köhler

The study of mechanosensation and cell polarity signalling pathways in Drosophila nephrocytes.

Contact type
First name
Postdoctural Researcher
Organisation 1
Hugh Robson Building
Organisation 2
15 George Square
Organisation 3
Edinburgh EH8 9XD
Work phone
+44 (0)131 651 1145

Personal profile

  • 2019 - Present:
    - Centre for Discovery Brain Sciences, Biomedical Sciences, University of Edinburgh (lab of Barry Denholm), Scotland, UK.
  • 2016 - 2019: 
    PostDoc -
    Department II of Internal Medicine and Center for Molecular Medicine, (lab of Prof. P. Brinkkötter), Cologne,Germany.
  • 2017 - 2017: 
    Research stay - (in the lab of Barry Denholm),  University of Edinburgh, Scotland.
  • 2011 - 2016PhD student -
    Department II of Internal Medicine,
    Nephrolab (lab of Prof. T. Benzing),


In the lab of Barry Denholm
I will study mechanosensation and cell polarity signalling pathways in Drosophila 
nephrocytes. I aim to setup novel 
in vivo 
imaging approaches to visualizes mechanotransduction processes and their downstream events in nephrocytes.

Relevant publications


  • Brinkkoetter PT, Bork T, Salou S, Liang W, Mizi A, Özel C, Koehler S, Hagmann HH, Ising C, Kuczkowski A, Schnyder S, Abed A, Schermer B, Benzing T, Kretz O, Puelles VG, Lagies S, Schlimpert M, Kammerer B, Handschin C, Schell C, Huber TB.
    Anaerobic Glycolysis Maintains the Glomerular Filtration Barrier Independent of Mitochondrial Metabolism and Dynamics. 
    Cell Rep
    2019 Apr 30;27(5):1551-1566.e5. doi: 10.1016/j.celrep.2019.04.012.


  • Sc

    hroeter CB, Koehler S, Kann M, Schermer B, Benzing T, Brinkkoetter PT,  Rinschen MM. 
    Protein half-life determines expression of proteostatic networks in podocyte differentiation. 
    . 2018 Sep;32(9):4696-4713.


  • Koehler S*
    , Brähler S*, Braun F, Hagmann H, Rinschen MM, Späth MR, Höhne M, Wunderlich FT, Schermer B, Benzing T, Brinkkoetter PT. 
    A T
    2A-peptide based knock-in mouse model for enhanced Cre recombinase activity and fluorescent labeling of podocytes.   K
    idney Int
    2017 Feb 7. pii: S0085-2538(16)30745-1.


  • Koehler S*
    , Brähler S*, Binz J, Hackl M, Hagmann H, Kuczkowski A, Vogt M, Wunderlich C, Wunderlich T, Schweda F, Schermer B, Benzing T, Brinkkoetter PT. 
    A Single and Transient Ca2+ Wave in Podocytes does not induce Changes in Glomerular Filtration and Perfusion.  
    Sci Rep
    2016 Oct 19;6:35400.
  • Rinschen MM, Schroeter CB, Koehler S, Ising C, Schermer B, Kann M, Benzing T, Brinkkoetter PT.  
    Quantitative deep-mapping of the cultured podocyte proteome uncovers shifts in proteostatic mechanisms during differentiation.   Am J Physiol Cell Physiol. 2016 Sep 1;311(3):C404-17.
  • Koehler S
    , Tellkamp F, Niessen C, Bloch W, Kerjaschki D, Schermer B, Benzing T, Brinkkoetter PT. 
    Par3A is dispensable for the function of the glomerular filtration barrier of the kidney.  Am J Physiol Renal Physiol. 2016 Jul 1;311(1):F112-9.
  • Ising C, Bharill P, Brinkkoetter S, Brähler S, Schroeter C, Koehler S, Hagmann H, Merkwirth C, Höhne M, Müller RU, Fabretti F, Schermer B, Bloch W, Kerjaschki D, Kurschat CE, Benzing T, Brinkkoetter PT. Prohibitin-2 depletion unravels extra-mitochondrial functions at the kidney filtration barrier.   Am J Pathol. 2016 May;186(5):1128-39.


  • Ising C, Koehler S, Brähler S, Merkwirth C, Höhne M, Baris OR, Hagmann H, Kann M, Fabretti F, Dafinger C, Bloch W, Schermer B, Linkermann A, Brüning JC, Kurschat CE, Müller RU, Wiesner RJ, Langer T, Benzing T, Brinkkoetter PT. Inhibition of insulin/IGF-1 receptor signaling protects from mitochondria-mediated kidney failure.   EMBO Mol Med. 2015 Feb 2;7(3):275-87.