Other areas of Research Interest
- Iatrogenic injury during orthopaedic surgery and chondroprotection (Amin & Hall, 2020).
- Septic arthritis - in particular the effects of toxins from Staphylococcus aureus on the viability of articular chondrocytes (Smith et al., 2013; Clement et al., 2022)
- Chondrocyte hypertrophy in the mammalian growth plate – a role for membrane transporters? (Loqman et al., 2013).
- Morphology and matrix metabolism by chondrocytes in strong and weak gel cultures, and on artificial membranes (Karim et al., 2016)
- Regulation of [Ca2+]i and pHi by in situ chondrocytes (Simpkin et al., 2007).
Team members
- Mr Mohammed Algarni (PhD student)
- Mr Zaid Alturkistani (PhD student)
- Mr Yousef Almajed (PhD student – second supervisor)
- Mr Abdulaziz Alomiery (PhD student – second supervisor)
- Ms Swati Shaji (MSc student)
- Ms Aneta Luczak (Visiting Research worker)
- Mr Nassai Herren (Visiting ERASMUS student – Karolinska Institutet, Sweden).
Collaborations
- Dr Anish Amin, Orthopaedics, University of Edinburgh.
- Prof. Asima Karim, University of Sharjah, UAE.
- Prof. Hamish Simpson, Orthopaedics, University of Edinburgh
- Dr Abduelmenem, Alashkham Anatomy, University of Edinburgh
- Dr Jennifer Paxton, Anatomy University of Edinburgh.
- Dr Peter Bush, University of Brighton.
Publications (Since 2016)
Karim, A., Bajbouj, K., Shafarin, J., Qaisar, R., Hall, A.C., Hamad, M. (2022). Iron overload induces oxidative stress, cell cycle arrest and apoptosis in chondrocytes. Frontiers in Cell and Developmental Biology 10: 821014. https://doi.org/10.3389/fcell.2022.821014
Karim, A., Bajbouj, K., Qaisar, R., Hall, A.C., Hamad, M. (2022). The role of disrupted iron homeostasis in the development and progression of arthropathy. J. Orthop. Res. 40(6):1243- 250. https://doi.org/10.1002/jor.25323
Clement, R., Hall, A.C., Wong, S.J., Howie, S.E.M., Simpson, H.W. (2022). Septic arthritis in an in vivo murine model induced by Staphylococcus aureus; a comparison between actions of the Hla toxin and the host immune response. Bone & Jt. Research 11(9):669–678. https://doi.org/10.1302/2046-3758.119.BJR-2022-0016.R1
Styczynska-Soczka, K., Amin, A.K., Simpson, A.H.W., Hall, A.C. (2021). Optimization and validation of a human ex vivo femoral head model for preclinical cartilage research and regenerative therapies. Cartilage. Vol. 13 (Suppl 2) 386S–397S. https://doi.org/10.1177/1947603520934534
Styczynska-Soczka, K., Amin, A.K., & Hall, A.C. (2021). Cell-associated Type I collagen in non-degenerate and degenerate human articular cartilage. J. Cell. Physiology 236:7672–7681. https://doi.org/10.1002/jcp.30418
Miller, R.P., Berlouis, M.E., Hall, A.G., Smith, I.D.M., Simpson, A.H.R.W., & Hall, A.C. (2021). Effect of antibiotics on Staphylococcus aureus α-toxin levels: implications for the treatment of septic arthritis. Cartilage 12(3) 362–376 https://doi: 10.1177/1947603519828433
Almajed, Y.A., Hall, A.C., Gillingwater, T.H., Alashkham, A. (2021). Anatomical, functional and biomechanical review of the glenoid labrum. J. Anatomy 240(4):761-771. http://doi.org/10.1111/joa.13582
Liu, C.L.S. & Hall, A.C. (2020). Optimising the composition of irrigation fluid to reduce the potency of Staphylococcus aureus α -toxin: a possible role in the treatment of septic arthritis. Cartilage 11(4):500-511. https://doi.org/10.1177/1947603518798888
Howard, T.A., Murray, I.R., Amin, A.K., Simpson, A.H.R.W. & Hall, A.C. (2020). Damage control articular surgery: maintaining chondrocyte health and minimising iatrogenic injury. Injury 51(2) S83-S89. https://doi.org/10.1016/j.injury.2019.10.072
Amin, A.K. & Hall, A.C. (2020). Raising the osmolarity of arthroscopic irrigating solutions may be chondroprotective: we must be kind to our joints during arthroscopy. Arthroscopy 36(12):3058-3060. https://doi.org/10.1016/j.arthro.2020.08.021
Hall, A.C. (2019). The role of chondrocyte morphology and volume in controlling phenotype – implications for osteoarthritis, cartilage repair and cartilage engineering. Curr. Top. Rheumatol. 21:38 https://doi.org/10.1007/s11926-019-0837-6
Karim, A., Amin, A.K. & Hall, A.C. (2018). The clustering and morphology of chondrocytes in normal and mildly-degenerate human femoral head cartilage studied by confocal laser scanning microscopy. J. Anatomy 232(4):686-698. doi: 10.1111/joa.12768.
Lin, Y-C., Hall, A.C., & Simpson, A.H.R.W. (2018). A novel joint organ culture model for evaluation of static and dynamic load on articular cartilage. Bone & Jt. Research 7(3): 205-212. doi: 10.1302/2046-3758.73BJR-2017-0320
Eltawil, N.M., Ahmed, S., Chan, L.H., Simpson, A.H.R.W. & Hall, A.C. (2018). Chondroprotection in a model of cartilage injury by raising the temperature and osmolarity of arthroscopic irrigation solutions. Cartilage 9(3) 313–320 https://doi.org/10.1177/1947603516688511
Smith, I.D.M., Milto, K.M., Doherty, C.J., Amyes, S.G.B., Simpson, A.H.R.W., & Hall, A.C. (2018). A potential key role of alpha-haemolysin of Staphylococcus aureus in mediating chondrocyte death in septic arthritis. Bone & Jt. Research 7(7): 457-467. https://doi: 10.1302/2046-3758.77.BJR-2017-0165.R1
Karim, A. & Hall, A.C. (2017). Chondrocyte morphology in stiff and soft agarose gels and the influence of fetal calf serum. J. Cell Physiology 232(5):1041-1052. https://doi.org/10.1002/jcp.25507
Amin, A.K., Simpson, A.H.R.W. & Hall, A.C. (2017). Iatrogenic articular cartilage injury: the elephant in the orthopaedic operating theatre. The surgeon’s role in chondroprotection. Bone & Jt. Journal (Editorial). 99(B)12:1555-6. doi: 10.1302/0301-620X.99B12.BJJ-2017-1337.
Lin, Y-C., Hall, A.C., Smith, I.D.M., Salter, D.M. & Simpson, A.H.R.W. (2016). Mapping chondrocyte viability, matrix glycosaminoglycan content, and water content on the surface of a bovine metatarsophalangeal joint. Cartilage 7(2):193-203.
Karim, A., & Hall, A.C. (2016). Hyperosmolarity normalizes serum-induced changes to chondrocyte properties in a model of cartilage injury. Europ. Cells & Mat. 31:205-220. DOI:10.22203/ecm.v031a14
Paterson, S.I., Eltawil, N.M., Simpson, A.H.R.W., Amin, A.K. & Hall, A.C. (2016). Drying of open animal joints in vivo subsequently causes cartilage degeneration. Bone Jt. Res. 5:137-144. https://doi.org/10.1302/2046-3758.54.2000594