Personal profile
2015 - Present: Royal Society of Edinburgh Personal Research Fellow funded by the Caledonian Research Fund. Centre for Discovery Brain Sciences, University of Edinburgh. 2011 - 2015: Postdoctoral Research Associate. Centre for Integrative Physiology, University of Edinburgh. 2010 - 2011: Postdoctoral Research Associate. University of Dundee. 2005 - 2009: PhD University of Dundee.- 2001 - 2005: B.Sc (Hons) Edinburgh
Research Theme
Synapses, Circuits and Behaviour
Research
Funding
Collaborations
Selected Publications
Selvaraj BT*, Livesey MR*, Zhao C, Gregory JM, James OT, Cleary EM, Chouhan AK, Gane AB, Perkins EM, Dando O, Lillico SG, Lee YB, Nishimura AL, Poreci U, Thankamony S, Pray M, Vasistha NA, Magnani D, Borooah S, Burr K, Story D, McCampbell A, Shaw CE, Kind PC, Aitman TJ, Whitelaw CBA, Wilmut I, Smith C, Miles GB, Hardingham GE, Wyllie DJA, Chandran S. (2018) C9ORF72 repeat expansion causes vulnerability of motor neurons to Ca2+-permeable AMPA receptor-mediated excitotoxicity. Nat. Comms. 9:347. Sances S, Bruijn LI, Chandran S, Eggan K, Ho R, Klim JR, Livesey MR, Lowry E, Macklis JD, Rushton D, Sadegh C, Sareen D, Wichterle H, Zhang SC, Svendsen CN. (2016) Modeling ALS with motor neurons derived from induced pluripotent stem cells. Nature Neuroscience. 16: 542-553. Livesey MR*, Magnani D*, Cleary E, Vasistha NA, James OT, Selvaraj BT, Burr K, Story D, Shaw CE, Hardingham GE, Wyllie DJ, Chandran S. (2016). Maturation and electrophysiological properties of human pluripotent stem cell-derived oligodendrocytes. Stem Cells. 34: 1040-1053. Livesey MR, Magnani D , Hardingham GE, Chandran S, Wyllie DJ. Functional properties of in vitro excitatory cortical neurons derived from human pluripotent stem cells. (2015). J. Physiol. 594:6573-6582. - James OT*, Livesey MR*, Qiu J, Dando O, Bilican B, Haghi G, Chandran S, Kind PC, Wyllie DJ. (2014). Characterisation of GABAA
and strychnine-sensitive glycine receptors in human pluripotent stem cell-derived cortical neurones. J. Physiol. 592: 4353-4363. -
Livesey MR*, Bilican B*, Qiu J, Rzechorzek NM, Haghi G, Burr K, Hardingham GE, Chandran S, Wyllie DJ. (2014). Maturation of AMPAR composition and the GABAAR reversal potential in hPSC-derived cortical neurons. J. Neurosci. 34: 4070-4075. -
Bilican B*, Livesey MR*, Haghi G, Burr K, Siller R, Hardingham GE, Wyllie DJA, Chandran S. (2014). Physiological oxygen levels and EGF withdrawal are required for scalable generation of functional cortical neurones from human pluripotent stem cells. PLoS One. 9: e85932. -
Livesey MR, Cooper MA, Lambert JJ, Peters JA. (2011). Rings of charge in the extracellular vestibule influence ion permeation within the 5-HT3A receptor. J. Biol. Chem . 286: 16008-17. Livesey MR, Cooper MA, Deeb TZ, Carland JE, Kozuska J, Hales TG, Lambert JJ, Peters JA. (2008). Structural determinants of Ca2+ permeability and conduction in the human 5-hydroxytryptamine type 3A receptor. J. Biol. Chem. 283: 19301-13 .