Dr Roseanne Rosario

Personal profile

• 2022 - present: Academic Track Lecturer (Reproductive Biology), University of Edinburgh
• 2014 - 2021: Postdoctoral Research Scientist, MRC Centre for Reproductive Health, University of Edinburgh
• 2009 - 2013: PhD in Biomedical Science, University of Auckland, New Zealand
• 2008: BSc(Hons) in Biomedical Science, University of Auckland, New Zealand

Research Theme

• Genes and Development   

Research

• Establishment of the human ovarian reserve and dynamics surrounding follicle loss
• Effects of chemotherapy on the human ovary and methods for chemoprotection
• Exploration of putative oogonial stem cells

Recent Funding and Awards

• 2023-2025: Academy of Medical Sciences Springboard Award: 'Defining mechanisms of chemotherapy-induced ovarian damage and potential for recovery
• 2022:  Society for Reproduction and Fertility - New Investigator Award 2022.
• 2021-2023: TENOVUS Scotland. ‘Defining cell-specific effects of chemotherapy in the human ovary and the potential for protection’ with Profs R Anderson and E Telfer.

Collaborations

• Professor Richard Anderson (University of Edinburgh)
• Professor Evelyn Telfer (University of Edinburgh)
• Professor Ian Adams (University of Edinburgh)
• A/Professor Karla Hutt (University of Melbourne)
• A/Prof Susana Chuva de Sousa Lopes (Leiden University)

Selected publications

Telfer EE, Grosbois J, Odey YL, Rosario R, Anderson RA. Making a good egg: human oocyte health, aging, and in vitro development. Physiol Rev 2023;103: 2623-2677.

Rosario R, Stewart HL, Choudhury NR, Michlewski G, Charlet-Berguerand N, Anderson RA. Evidence for a fragile X messenger ribonucleoprotein 1 (FMR1) mRNA gain-of-function toxicity mechanism contributing to the pathogenesis of fragile X-associated premature ovarian insufficiency. FASEB J 2022;36: e22612.

Rosario R, Cui W, Anderson RA. Potential ovarian toxicity and infertility risk following targeted anti-cancer therapies. Reprod Fertil 2022;3: R147-r162.

Rosario R, Anderson RA. (2021) Novel approaches to fertility restoration in women with premature ovarian insufficiency. Climacteric. 24(5):491-497.

Rosario R, Anderson RA. (2021) Recent advances in unravelling the genetic aetiology of premature ovarian insufficiency. Current Opinion in Endocrine and Metabolic Research. 18:8-14.

Rosario R, Anderson RA. (2020) The molecular mechanisms that underlie fragile X-associated premature ovarian insufficiency: is it RNA or protein based? Molecular Human Reproduction 26(10):727-737

Rosario R, Stewart HL, Walshe E, Anderson RA. (2020) Reduced retinoic acid synthesis accelerates prophase I and follicle activation. Reproduction. 160:331-41.

Hartanti MD, Rosario R, Hummitzsch K, Bastian NA, Hatzirodos N, Bonner WM, Bayne RA, Irving-Rodgers HF, Anderson RA, Rodgers RJ. (2020) Could perturbed fetal development of the ovary contribute to the development of polycystic ovary syndrome in later life? PLoS One 15:e0229351.  

Liu M, Hummitzsch K, Hartanti MD, Rosario R, Bastian NA, Hatzirodos N, Bonner WM, Irving-Rodgers HF, Laven JSE, Anderson RA et al. (2020) Analysis of expression of candidate genes for polycystic ovary syndrome in adult and fetal human and fetal bovine ovaries. Biology of Reproduction 103:840-53.

Rosario R, Crichton JH, Stewart HL, Childs AJ, Adams IR, Anderson RA (2019) Dazl determines primordial follicle formation through the translational regulation of Tex14. FASEB J. 33:14221-33.

Information for students:

Willingness to discuss research projects with undergraduate and postgraduate students: YES - please click here