Interfacial Tissue Engineering
Tissue engineering seeks to manufacture replacement tissues in the laboratory using a combination of biological and engineering principles.
While many groups concentrate on the engineering of particular tissues in isolation, a subset of tissue engineering research has emerged recently, called interfacial tissue engineering, which attempts to re-establish the complex interfaces found at the junctions between tissues as described above.
The Paxton Lab focusses on interfacial tissue engineering of the musculoskeletal system and our research can be split into three related and complementary topics;
- Understanding the mechanisms of musculoskeletal tissue interface formation in vitro Using 2D and 3D culture systems, we are investigating cellular co-cultures to examine their behaviour, organisation and interaction.
- The manufacture of complete multiphasic tissue structures for implantation Using a combination of scaffolds and cell populations, we are investigating the manufacture of complete bone-to-bone ligaments, osteochondral plugs and bone-tendon replacements for implantation following injury.
- Developing 3-dimentional in vitro models for understanding musculoskeletal disease and repair. Our 3D culture systems can be a useful model for the study of musculoskeletal disease or for the investigation into repair options following injury.
Liew, M. Y., Mortimer, J., Paxton, J. Z., Tham, S., & Rust, P. (2021) Histomorphology of the subregions of the scapholunate ligament and its enthesis Journal of Wrist Surgery DOI: 10.1055/s-0041-1723792
Alsaykhan H. and Paxton J.Z. (2020) Investigating materials and orientation parameters for the creation of a 3-D musculoskeletal interface co-culture model. Regenerative Biomaterials 7(4) 413-425
Kelsey A., McCulloch V., Findlater G., Gillingwater T., Paxton J.Z. Anatomical sciences at the University of Edinburgh: Initial experiences of teaching anatomy. online. Translational Research in Anatomy 19 2020
Wang A., Williams R.L., Jumbu N., Paxton J.Z., Davis E.T., Snow M.A., Ritchie A.C., Johansson C.B., Sammons R.L. Grover L.M. (2016) Development of tissue engineered ligaments with titanium spring reinforcement. Accepted in RSC Advances.
Smith A.M., Paxton J.Z., Hung Y.P., Hadley M.J., Bowen J., Williams R.L., Grover L.M. (2015). Nanoscale crystallinity modulates cell proliferation on plasma sprayed surfaces. Materials Science & Engineering C. 48(5-10).
Wudebwe U.N.G., Bannerman A., Goldberg-Oppenheimer P., Paxton J.Z., Williams R.L., Grover L.M. (2015). Exploiting cell-mediated contraction and adhesion to structure tissues in vitro. Philosophical transactions B. 370(1661).
Lebled C., Grover L.M, Paxton J.Z. (2014) Combined decellularisation and dehydration improves the mechanical properties of tissue-engineered sinews. Journal of Tissue Engineering. doi: 10.1177/2041731414536720
Jordan R., Saithna A., Paxton J.Z., Grover L., Krikler S.J., Thompson P. (2014) Early failure of tantalum patellar augments in the post-patellectomy knee. Current Orthopaedic Practice. In press
Tan Y., Zhao Z., Paxton J.Z., Grover L.M. (2014) Synthesis and in vitro degradation of a novel magnesium oxychloride cement. J Biomed Mater Res A. 2014 Mar 13 doi:10.1002/jbm.a.35166
Koburger S.K., Bannerman A., Grover L.M., Mueller F., Bowen J., Paxton J.Z. (2013) A novel method for monitoring mineralisation in hydrogels at the engineered hard/soft tissue interface. Biomaterials Science, 2, 41-51
Bannerman A., Paxton J.Z., Grover L.M. (2013) Imaging the hard/soft tissue interface. Biotechnology Letters. Epub. PMID:24129952
Paxton J.Z., Baar K., Grover L.M. (2012) Current progress in enthesis repair: strategies for interfacial tissue engineering. Orthopaedic and Muscular system special issue. 2012 S1.
Paxton J.Z., Wudebwe U., Wang A., Woods D., Grover L.M. (2012) Monitoring sinew contraction during formation of tissue-engineered fibrin-based ligament constructs. Tissue Eng Part A 18(15-16):1596-607
Paxton J.Z., Hagerty P., Andrick J.J., Baar K. (2012) Optimizing an intermittent stretch paradigm using ERK1/2 phosphorylation results in increased collagen synthesis in engineered ligaments. Tissue Eng Part A 18(3-4) 277-84.
Jennifer Paxton publication list (pdf)
Information for students:
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