My research focuses on the control of secretory vesicle trafficking in regulated exocytosis in endocrine and neuronal cells. [scald=874:sdl_editor_representation {"alt":"","caption":""}] Personal profile Diploma in Biology, University of Cologne PhD, University of Cologne Research My research focuses on the control of secretory vesicle trafficking in regulated exocytosis in endocrine and neuronal cells, in particular the biogenesis of vesicles at the Golgi apparatus and how the actin cortex regulates vesicle passage to the plasma membrane. Most of my research work is based on the application of light microscopic methods such as time lapse imaging, total internal reflection fluorescence microscopy, high resolution confocal microscopy and so on. I also head the Confocal and Advanced Light Microscopy (CALM) Facility in the Queen’s Medical Research Institute at Little France. You can find more information about this facility and microscopy-related topics on the their website. Confocal and Advanced Light Microscopy Facility website Funding Moray Endowment Fund Society for Endocrinology University of Edinburgh Development Trust Collaborations Mike Ludwig, University of Edinburgh Sutherland MacIver, University of Edinburgh Alan Prescott, Univeristy of Dundee John Lucocq, University of Dundee Publications Monteiro O, Wiegand UK, Ludwig M. (2011) Vesicle degradation in dendrites of magnocellular neurones of the rat supraoptic nucleus. Neurosci Lett. 489(1):30-3 Antoni FA, Wiegand UK, Black J, Simpson J (2006) Cellular localization of adenylyl cyclase: A post-genomic perspective. Neurochemical Research 31(2): 287-295 Apps DK, Cousin M, Duncan RR, Wiegand UK, Shipston MJ (2005) The life cycle of secretory vesicles: implications for dendritic transmitter release. In: Dendritic Neurotransmitter Release (ed M Ludwig) pp 35-53 Wiegand UK, Duncan RR, Greaves J, Chow RH, Shipston MJ, Apps DK (2003) Red, yellow, green go! - A novel tool for microscopic segregation of secretory vesicle pools according to their age. Biochemical Society Transactions 31(4): 851-856 Duncan RR, Greaves J, Wiegand UK, Matskevich I, Bodammer G, Apps DK, Shipston MJ, Chow RH (2003) Functional and spatial segregation of secretory vesicle pools according to vesicle age. Nature 422(6928): 176-180 Rolly Wiegand publication list (pdf) This article was published on 2022-10-17
