Personal profile
- Present: Sir Henry Dale Fellow, University of Edinburgh
- 2017 - 2018: Wellcome Trust ISSF3 Fellow, University of Edinburgh
- 2012 - 2017: Sir Henry Wellcome Postdoctoral Fellow, University of Edinburgh, UK
- 2011 - 2012: HHMI Fellow, Janelia Research Campus, USA
Education
PhD, Columbia University, USA
Research Theme
Synapses, Circuits and Behaviour
Research
Long-term memory involves interactions dispersed across cortical circuits, but how these interactions are coordinated is not known. Hippocampus and the medial entorhinal cortex are thought to play pivotal roles in the formation and coordination of cortical memory networks. However, organising principles for distribution of entorhinal and hippocampal projections to the cortex have not been established thoroughly and how these projections play roles in the formation and shaping of cortical network activity is unknown. The lab investigates these unknowns at a circuit level using advanced anatomical, electrophysiological, optogenetic and live calcium imaging methods.
Funding
Team members
- Rafael Lemarchand, PhD candidate Wellcome Translational Neuroscience DTP
- Sau Yee Tsoi, PhD candidate, EASTBIO DTP
- Daniel Lewis-Fallows, PhD candidate, SIDB DTP
- Jinghua Yang, PhD candidate
- Sara Gomez-Arnaiz, PhD, Postdoctoral Fellow.
- Dr Alessandro Di Filippo, (co-supervised with Prof Matthew Nolan)
- Sau Yee Tsoi, MSc (co-supervised with Prof Matthew Nolan)
Collaborations
- Dr Benjamin Grewe (Institue of Neuroinformatics, University of Zurich)
- Dr Matthias Henning (School of Informatics, University of Edinburgh)
- Dr Emma Wood (CDBS, University of Edinburgh)
- Prof Matthew Nolan (CDBS, University of Edinburgh)
- Dr. Sarah Wade (School of Mathematics, UoE)
Current PhD Opportunities
Please contact Dr. Surmeli: gsurmeli@exseed.ed.ac.uk to enquire about current job vacancies and PhD opportunities.
Publications
Tsoi, S.Y., Oncul, M., Svahn, E., Robertson, M., Bogdanowicz, Z., McClure, C., and Sürmeli, G. (2022). Telencephalic outputs from the medial entorhinal cortex are copied directly to the hippocampus. Elife 11.
Gerlei, K.Z., Brown, C.M., Sürmeli, G., and Nolan, M.F. (2021). Deep entorhinal cortex: from circuit organization to spatial cognition and memory. Trends Neurosci. 44, 876–887.
Pastoll H1, Garden DL1, Papastathopoulos I2, Sürmeli G1, Nolan MF1. Inter- and intra-animal variation in the integrative properties of stellate cells in the medial entorhinal cortex. Elife. 2020 Feb 10;9. pii: e52258. doi: 10.7554/eLife.52258.
Sürmeli, G., Cosmin-Marcu, D., McClure, C., Pastoll, H., Garden, D., Nolan, M.F., Molecularly defined circuitry reveals input-output segregation in deep layers of the medial entorhinal cortex. (2015) Neuron 88(5). PMCID: PMC4675718
Ramsden, H., Sürmeli, G., McDonagh, S. G., and Nolan, M.F., Laminar and Dorsoventral Molecular Organization of the Medial Entorhinal Cortex Revealed by Large-scale Anatomical Analysis of Gene Expression. (2015) PLOS Comp. Biol., 11(1). PMCID: PMC4304787
Gonzalez-Sulser, A., Parthier, D., Candela, A., McClure, C., Pastoll, H., Garden, D., Sürmeli, G., and Nolan, M. F., GABAergic projections from the medial septum selectively inhibit interneurons in the medial entorhinal cortex. (2014) J. Neurosci. 34(50). PMCID: PMC4261098.
Lacombe, J., Hanley, O., Jung, H., Philippidou, P., Surmeli, G., Grinstein., J, Dasen, J.S. Genetic and functional modularity of Hox activities in the specification of limb-innervating motor neurons. (2013). PLoS Genet. 9(1).
Jessell, T.M., Sürmeli, G., Kelley, J.S. Motor Neurons and the Sense of Place. (2011). Neuron 72, 1-6.
Sürmeli, G., Akay, T., Ippolito, G., Tucker, P.W. and Jessell, T.M. (2011). Patterns of Spinal Sensory-Motor Connectivity Prescribed by a Dorsoventral Positional Template. Cell 147, 653-665. PMCID: PMC3238499.